Stem Cell Research

Research into the reprogramming of somatic cells into pluripotent stem cells received the Nobel Prize in 2012. The long-term importance of this research resides in the use of stem cells for regenerative therapies for the short term., However these cells represent a potential unlimited source of highly physiologically relevant cells, akin to human primary cells, that can be used as drug discovery reagents. The process of differentiating stem cells into the somatic cell of choice is a long process requiring careful culturing. The process typically utilizes immunofluorescence techniques to determine progenitor cells and terminally differentiated somatic cells. The Agilent BioTek imaging products with liquid handling and Agilent BioTek BioSpa 8 automated CO₂ incubator have been designed to enable automated stem cell differentiation.

Application Notes:

• Automated Media Exchange for Spheroid Cultures Using a Novel MultiFlo FX Accessory
• An Automated Walk-Away System to Perform Differentiation of 3D Mesenchymal Stem Cell Spheroids
• The Impact of a 3-Dimensional Human Liver Microtissue Model on Long-term Hepatotoxicity Studies
• Automation and Image-Based Analysis of a Hanging Drop Micro-Hole Plate Model to Create and Differentiate 3D Mesenchymal Stem Cell Spheroids for Downstream Tissue Formation

• Long-Term Hepatotoxicity Studies using Cultured Human iPSC-Derived Hepatocytes

Related Products:

• Agilent BioTek BioSpa Live Cell Imaging System
• Agilent BioTek Cytation 7 Cell Imaging Multi-Mode Reader
• Agilent BioTek Cytation 5 Cell Imaging Multi-Mode Reader
• Agilent BioTek Cytation 1 Cell Imaging Multi-Mode Reader

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For Research Use Only. Not for use in diagnostic procedures.

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